(2008) Human pulmonary imaging and spectroscopy with hyperpolarized 129Xe at 0.2 T. D., Frederick, E., Hatabu, H., Hersman, F. (2007) Advances in magnetic resonance imaging of lung physiology. L., Emami, K., Kadlecek, S., Yu, J., Ishii, M., Rizi, R. (2007) Retrospective cine He-3 ventilation imaging under spontaneous breathing conditions: a non-invasive protocol for small-animal lung function imaging. Stupar, V., Canet-Soulas, E., Gaillard, S., Alsaid, H., Beckmann, N., Cremillieux, Y. (2007) 3He MRI in mouse models of asthma. P., Mistry, N., Schwartz, D., Johnson, G. (2006) Hyperpolarized He-3 and perfluorocarbon gas diffusion MRI of lungs. (2006) Early emphysematous changes in asymptomatic smokers: detection with 3He MR imaging. (2003) Dynamic radial projection MRI of inhaled hyperpolarized 3He gas. N., Kasuboski, L., Swift, A., Fichele, S., Woodhouse, N., Griffiths, P. (2003) Distal airways in humans: dynamic hyperpolarized 3He MR imaging – feasibility. (2002) MRI of the lungs using hyperpolarized noble gases. (2007) NMR Studies of Angular Momentum Transfer and Nuclear Spin Relaxation. (2004) Production of hyperpolarized 129Xe gas without nitrogen by optical pumping at 133Cs D 2 line in flow system. Zhou, X., Sun, X., Luo, J., Zeng, X., Liu, M., Zhan, M. (1998) Theory of spin-exchange optical pumping of 3He and 129Xe. (1985) Experimental determination of the rate constants for spin exchange between optically pumped K, Rb, and Cs atoms and 129Xe nuclei in alkali-metal-noble-gas van der Waals molecules. Zeng, X., Wu, Z., Call, T., Miron, E., Schreiber, D., Happer, W. (1997) Spin-exchange optical pumping of noble-gas nuclei. Application à l’expérience de Stern et Gerlach et à la résonance magnétique. (1950) Quelques suggestions concernant la production optique et la détection optique d’une inégalité de population des niveaux de quantifigation spatiale des atomes. (1994) Biological magnetic resonance imaging using laser-polarized 129Xe. D., Driehuys, B., Happer, W., Saam, B., Springer, C. (1991) High-field NMR of adsorbed xenon polarized by laser pumping. Raftery, D., Long, H., Meersmann, T., Grandinetti, P. and delivery of hyperpolarized noble gases.Many of the problems that are likely to be encountered in practical experiments and the corresponding detailed approaches to overcome them are also discussed. The storage and delivery strategies of hyperpolarized gases for in vivo imaging are discussed. In this chapter, the underlying physics of spin exchange optical pumping for production of hyperpolarized noble gases is explained and the basic components and procedures for building a polarizer are described. These gases obtain a highly polarized state by employing a spin exchange optical pumping technique. Hyperpolarized noble gases ( 3He and 129Xe) can provide NMR signal enhancements of 10,000 to 100,000 times that of thermally polarized gases and have shown great potential for applications in lung magnetic resonance imaging (MRI) by greatly enhancing the sensitivity and contrast.

Gas inhale mr contrast